TSHR and ASPHD1

Data Source:
BioGRID (two hybrid)

		TSHR	ASPHD1
Description		thyroid stimulating hormone receptor	aspartate beta-hydroxylase domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Receptor Complex	Integral Component Of Membrane
	Molecular Function	Thyroid-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Protein-containing Complex Binding	Dioxygenase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Thyroid-stimulating Hormone Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Glycoprotein Cellular Response To Thyrotropin-releasing Hormone	Peptidyl-amino Acid Modification
Pathways		Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Thyrotropin alfa
Diseases		Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Graves' disease ( 21841780 22922229) Hair morphology ( 19896111) Male sexual orientation ( 29217827) Maximal oxygen uptake response ( 25729143) Obstetric antiphospholipid syndrome ( 28424481) Optic nerve measurement (rim area) ( 20395239) Smooth-surface caries ( 24556642) Thyroid stimulating hormone levels ( 30367059 32769997) Tourette syndrome ( 30818990) Uric acid levels ( 21294900) Urinary albumin excretion ( 32277301) Visceral fat ( 22589738)	Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		38 interacting genes: ACTB ADORA1 ADRB2 ASPHD1 BNIP1 CALR CANX CD81 CRADD FLNB FN1 GNA11 GNA12 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS HNRNPA1 HSPA5 JAK1 JAK2 JPH3 LHCGR MID1IP1 MOG PIK3R1 PTDSS1 RABAC1 RUNDC3A SCRIB STAT3 SYT1 TMCO3 TMEM119 TSHB	2 interacting genes: FBXO7 TSHR
Entrez ID		7253	253982
HPRD ID		04537	14139
Ensembl ID		ENSG00000165409	ENSG00000174939
Uniprot IDs		A0A0A0MTJ0 P16473	Q5U4P2
PDB IDs		1XUM 2XWT 3G04
Enriched GO Terms of Interacting Partners?
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