STAT1 and CASP3

Data Source:
BioGRID (enzymatic study)

		STAT1	CASP3
Description		signal transducer and activator of transcription 1	caspase 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Death-inducing Signaling Complex Neuronal Cell Body Membrane Raft
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin-like Protein Ligase Binding Cadherin Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding	Protease Binding Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Death Receptor Binding Protein Binding Peptidase Activity Phospholipase A2 Activator Activity Protein-containing Complex Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Defense Response Positive Regulation Of Transcription Of Notch Receptor Target Receptor Signaling Pathway Via JAK-STAT Blood Circulation Macrophage Derived Foam Cell Differentiation Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-alpha Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Interferon-beta Cellular Response To Interferon-beta Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Renal Tubule Development Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Cellular Response To Interferon-gamma Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation	Luteolysis Response To Hypoxia B Cell Homeostasis Apoptotic DNA Fragmentation Proteolysis Apoptotic Process Cellular Response To DNA Damage Stimulus Axonal Fasciculation Heart Development Sensory Perception Of Sound Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To UV Response To Glucose Response To X-ray Regulation Of Macroautophagy Protein Processing Cytokine-mediated Signaling Pathway Hippocampus Development Neuron Differentiation Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Response To Nicotine Hippo Signaling Wound Healing Response To Drug Response To Hydrogen Peroxide T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Neuron Apoptotic Process Cell Fate Commitment Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Activated T Cell Proliferation Response To Antibiotic Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Cell Differentiation Response To Glucocorticoid Neuron Apoptotic Process Anterior Neural Tube Closure Leukocyte Apoptotic Process Cellular Response To Staurosporine Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Amyloid-beta Formation
Pathways		Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Degradation of the extracellular matrix Signaling by Hippo NADE modulates death signalling Stimulation of the cell death response by PAK-2p34 Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling
Drugs			Pamidronic acid Acetylsalicylic acid Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid Emricasan Incadronic acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Glycyrrhizic acid
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Birth weight ( 31043758) Height ( 31562340) Inflammatory bowel disease ( 23128233) JT interval (sulfonylurea treatment interaction) ( 27958378) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer (SNP x SNP interaction) ( 24325914) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 26394269) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 26316170) Systemic sclerosis ( 29293537)	Blood protein levels ( 28240269) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Kawasaki disease ( 33106546)
Interacting Genes		108 interacting genes: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CDC42 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DDX6 DOT1L DUSP2 DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 FADD FANCC FGFR3 FGFR4 FLT1 FOS FTH1 FYN GFAP GTF2I HADH HLA-B HSF1 HSP90AB1 HSPA8 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK MT-ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RACK1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTB SPTBN1 SRC STAT2 STAT3 STAT4 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBE2I VDR XPO1 ZNF467	157 interacting genes: ACIN1 ADD1 AFP AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ARNT ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SNRNP70 SOCS5 SOHLH1 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16
Entrez ID		6772	836
HPRD ID		02777	02799
Ensembl ID		ENSG00000115415	ENSG00000164305
Uniprot IDs		P42224	P42574
PDB IDs		1BF5 1YVL 2KA6 3WWT	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4
Enriched GO Terms of Interacting Partners?
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