SP1 and NUP62

Data Source:
BioGRID (pull down, two hybrid)

		SP1	NUP62
Description		Sp1 transcription factor	nucleoporin 62
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GO Annotations	Cellular Component	Chromatin Euchromatin Nucleus Nucleoplasm Cytoplasm Transcription Repressor Complex Protein-DNA Complex	Spindle Pole Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Centrosome Nuclear Membrane Host Cell Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Histone Acetyltransferase Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding Repressing Transcription Factor Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Kinesin Binding Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding Protein-containing Complex Binding PTB Domain Binding Hsp90 Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Viral Process Cellular Response To Insulin Stimulus Response To Hydroperoxide SnRNA Transcription By RNA Polymerase II Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation By Host Of Viral Transcription Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Endothelial Cell Proliferation	Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Mitotic Metaphase Plate Congression Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Spermatogenesis Cell Aging Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Viral Process Protein Sumoylation Viral Transcription Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication Regulation Of Mitotic Spindle Organization Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Centriole Assembly Regulation Of Cellular Response To Heat Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome
Pathways		PPARA activates gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Activation of gene expression by SREBF (SREBP) Oncogene Induced Senescence RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Estrogen-dependent gene expression	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) Hypospadias (moderate to severe) ( 31856834) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 27863252) Parkinsonism in frontotemporal lobe dementia ( 29724592) Percentage gas trapping ( 26030696) Progressive supranuclear palsy ( 30089514) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		146 interacting genes: AATF AHR AKT1 AR ARHGAP21 ARNT ATF7IP ATF7IP2 BCL11B BCL6 BCOR BRCA1 CASP3 CASP6 CASP7 CBX5 CCNA1 CCNA2 CCND1 CD2 CDK1 CDK2 CEBPB CSNK2A1 CTCFL CTNNB1 DDX5 DROSHA E2F1 E2F2 E2F3 EGR1 ELF1 EP300 ESR1 ESR2 ESRRA ESRRB ESRRG ETS1 GABPA GATA1 GATA3 GATA4 HBZ HCFC1 HDAC1 HDAC2 HIF1A HINT1 HLTF HMGA1 HNF4A HOXC11 HSPA8 HTT IL1B JUN KIF1A KLF10 KLF4 KLF6 LDB1 LMO2 MAPK1 MAPK3 MAPK8 MBD1 MEF2C MEF2D MIER1 MIS18BP1 MSX1 MTREX MYC MYCN MYOD1 MYOG NAP1L1 NCOR1 NCOR2 NEPRO NFKB1 NFKB2 NFYA NFYB NFYC NKX3-1 NOS3 NPM1 NR2F1 NR5A1 NUP62 OGT PARP1 PER3 PML POGZ POU2F1 PPIG PPP1R13L PRKCZ PRKDC PSIP1 PSMC5 PURA RARA RB1 RBBP4 RBL1 REL RELA RNF4 RORA RXRA SENP6 SF3A1 SHC1 SMAD2 SMAD3 SMAD4 SMARCC1 SMARCC2 SOX10 SOX8 SP3 SP4 SREBF1 SREBF2 SRF SUB1 SUMO2 TAF4 TAL1 TBP TLX3 TP53 TP73 TPI1 USP39 VEGFA VHL YY1 ZBTB16 ZBTB2 ZBTB7A	91 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCDC153 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 DDX3X DGCR6 DPPA3 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 HSPB11 IDH1 IFT20 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NFX1 NUP153 NUP214 NUP54 NUP58 NUP88 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PHF21A PIN1 PTMA RANBP2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6
Entrez ID		6667	23636
HPRD ID		01796	05782
Ensembl ID		ENSG00000185591	ENSG00000213024
Uniprot IDs		P08047	A0A024QZF1 P37198
PDB IDs		1SP1 1SP2 1VA1 1VA2 1VA3 6PV0 6PV1 6PV2 6PV3 6UCO 6UCP	2H4D 5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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