NUP62 and ADAM15

Data Source:
BioGRID (two hybrid)

		NUP62	ADAM15
Description		nucleoporin 62	ADAM metallopeptidase domain 15
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nuclear Envelope Annulate Lamellae Nuclear Pore Nucleoplasm Cytoplasm Centrosome Nuclear Membrane Host Cell Nuclear Pore Central Transport Channel Mitotic Spindle Flemming Body Ribonucleoprotein Complex	Acrosomal Vesicle Extracellular Space Plasma Membrane Adherens Junction Cell Surface Integral Component Of Membrane Motile Cilium Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding Phospholipid Binding Structural Constituent Of Nuclear Pore Kinesin Binding Signaling Receptor Complex Adaptor Activity Hsp70 Protein Binding SH2 Domain Binding Ubiquitin Binding Protein-containing Complex Binding PTB Domain Binding Hsp90 Protein Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process	Regulation Of Glycolytic Process RNA Export From Nucleus MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Mitotic Metaphase Plate Congression Centrosome Cycle Mitotic Centrosome Separation Cell Surface Receptor Signaling Pathway Spermatogenesis Cell Aging Cell Death Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Viral Process Protein Sumoylation Viral Transcription Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of Ras Protein Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Positive Regulation Of Centriole Replication Regulation Of Mitotic Spindle Organization Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Centriole Assembly Regulation Of Cellular Response To Heat Positive Regulation Of Mitotic Cytokinetic Process Positive Regulation Of Protein Localization To Centrosome	Angiogenesis Negative Regulation Of Cell-matrix Adhesion Immune Response To Tumor Cell Proteolysis Apoptotic Process Cell-matrix Adhesion Integrin-mediated Signaling Pathway Male Gonad Development Extracellular Matrix Disassembly Extracellular Matrix Organization Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Collagen Catabolic Process Tissue Regeneration Innate Immune Response Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Receptor Binding Cellular Response To Phorbol 13-acetate 12-myristate Response To Hypobaric Hypoxia
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation	Degradation of the extracellular matrix Invadopodia formation
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Mosquito bite size ( 28199695) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systemic lupus erythematosus ( 28714469)
Interacting Genes		91 interacting genes: ABI2 ADAM15 AGR3 ARFIP2 ATF7IP2 ATXN7 BFSP1 BLOC1S6 C14orf119 C1orf216 CAVIN3 CCDC121 CCDC146 CCDC150 CCDC153 CCHCR1 CENPU CEP57L1 CLIC1 CRCT1 DDX3X DGCR6 DPPA3 DTNB DYNLT1 FABP3 GOPC GORASP2 GTF2E2 HAUS1 HGS HSF2 HSF4 HSPB11 IDH1 IFT20 IK IKBIP IPO5 ISCU KANSL1 KIFC3 KLHL32 KPNA1 KPNA2 KPNB1 KRT1 KRT20 KRT3 KRT6A KRT6B KRT75 LMO2 LNX1 MUC1 MXD3 MYO15B NFX1 NUP153 NUP214 NUP54 NUP58 NUP88 NUP98 NUTF2 NXF1 NXF2 OGT OIP5 OTUD6A PBX2 PELI2 PHF21A PIN1 PTMA RANBP2 SMARCE1 SNAPC5 SP1 SSC5D SUOX THAP1 TLE4 TRAF3 TRIML2 TXLNA TXN USHBP1 WASHC3 XPO1 XPO6	34 interacting genes: ABL1 ARHGEF6 ARHGEF7 ATXN1 BANP FHL3 FYN GRB2 HCK LCK LYN MAD2L2 NCK1 NPHP1 NUP62 ODAM PACSIN3 RBPMS SH3D19 SH3GL2 SH3GLB1 SH3PXD2A SH3RF1 SH3RF3 SNX30 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SP4 SRC TRIP13 YES1
Entrez ID		23636	8751
HPRD ID		05782	05674
Ensembl ID		ENSG00000213024	ENSG00000143537
Uniprot IDs		A0A024QZF1 P37198	Q13444
PDB IDs		2H4D 5IJN 5IJO
Enriched GO Terms of Interacting Partners?
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