SOD3 and KCNIP3

Data Source:
BioGRID (two hybrid)

		SOD3	KCNIP3
Description		superoxide dismutase 3	potassium voltage-gated channel interacting protein 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Golgi Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Heparin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding
	Biological Process	Response To Hypoxia Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Response To Copper Ion	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species	Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Major depressive disorder ( 23377640)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		9 interacting genes: ASPH FBLN5 GOLM2 KCNIP1 KCNIP3 SGTA SGTB UBQLN1 UBQLN2	26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16
Entrez ID		6649	30818
HPRD ID		01708	05232
Ensembl ID		ENSG00000109610	ENSG00000115041
Uniprot IDs		A0A140VJU8 P08294	A0A024RE22 Q9Y2W7
PDB IDs		2JLP	2E6W
Enriched GO Terms of Interacting Partners?
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