KCNIP3 and GRK2

Data Source:
BioGRID (pull down, enzymatic study)

		KCNIP3	GRK2
Description		potassium voltage-gated channel interacting protein 3	G protein-coupled receptor kinase 2
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus	Cytoplasm Cytosol Plasma Membrane Cilium Membrane Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Alpha-2A Adrenergic Receptor Binding Edg-2 Lysophosphatidic Acid Receptor Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of The Force Of Heart Contraction By Chemical Signal G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Heart Development Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Viral Genome Replication Receptor Internalization Positive Regulation Of Catecholamine Secretion Negative Regulation Of Striated Muscle Contraction Viral Entry Into Host Cell Cardiac Muscle Contraction Negative Regulation Of Relaxation Of Smooth Muscle
Pathways		Phase 1 - inactivation of fast Na+ channels	Calmodulin induced events G alpha (q) signalling events G alpha (s) signalling events Activation of SMO Activation of SMO Cargo recognition for clathrin-mediated endocytosis
Drugs			ATP
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	51 interacting genes: ADRA2A ADRB2 AGTR1 AKAP12 ARRB1 ARRB2 BDKRB2 CAPN2 CAV1 CCR4 CCR5 CSNK2B EGF EGFR EPHA2 ERBB2 FBXO25 FPR1 FSHR GIT1 GIT2 GNA15 GNAQ GNB2 GNB3 GRM1 HDAC6 KCNIP3 MAPK3 MC4R MDM2 NCS1 OPRD1 PDC PDCL PDE6G PEBP1 PIK3CG PLCB1 PRKACA PRKCA PRKCB PRKCD PRKCG RASGRF1 RCVRN RHO RPLP2 SNCA SRC TPM2
Entrez ID		30818	156
HPRD ID		05232	00182
Ensembl ID		ENSG00000115041	ENSG00000173020
Uniprot IDs		A0A024RE22 Q9Y2W7	A0A0S2Z392 P25098
PDB IDs		2E6W	1BAK 3CIK 3KRW 3KRX 3V5W 4MK0 4PNK 5HE1 5UKK 5UKL 5UUU 5UVC 5WG3 5WG4 5WG5 6C2Y 6U7C 7K7L 7K7Z
Enriched GO Terms of Interacting Partners?
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