HLTF and UBE2A

Data Source:
BioGRID (enzymatic study)

		HLTF	UBE2A
Description		helicase like transcription factor	ubiquitin conjugating enzyme E2 A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane	Chromatin XY Body Nucleoplasm Cytosol HULC Complex
	Molecular Function	DNA Binding RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Chromatin Organization Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II	Protein Polyubiquitination Blastocyst Hatching DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cell Population Proliferation Response To UV Protein Ubiquitination Histone Ubiquitination Histone H2A Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Maternal Process Involved In Female Pregnancy Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Brain connectivity ( 23471985)
Interacting Genes		13 interacting genes: CDK9 DCAF1 EEF1G EWSR1 HSPA8 SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4	26 interacting genes: CBX5 CDK1 CDK2 CDK9 CDKN2A CRMP1 EEF1D H2BC21 HLTF KCMF1 MDM2 PCNA PRKN RAD18 RC3H1 RNF20 RNF4 RNF40 SDCBP TP53 TRIM27 UBA1 UBR1 UBR3 UBR5 ZMYM2
Entrez ID		6596	7319
HPRD ID		04461	02422
Ensembl ID		ENSG00000071794	ENSG00000077721
Uniprot IDs		A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527	A0A0D9SG71 P49459
PDB IDs		2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F 6KCS	6CYO 6CYR
Enriched GO Terms of Interacting Partners?
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