SMARCA2 and SS18

Data Source:
HPRD (in vitro, in vivo)

		SMARCA2	SS18
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	SS18 subunit of BAF chromatin remodeling complex
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex	Nucleus Microtubule Cytoskeleton SWI/SNF Complex NpBAF Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding	Protein Binding Nuclear Receptor Coactivator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Microtubule Cytoskeleton Organization Cell Morphogenesis Intracellular Signal Transduction Response To Drug Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Neuronal Stem Cell Population Maintenance
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Diseases			Synovial sarcoma
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Brain morphology (MOSTest) ( 32665545) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955)	Autoimmune thyroid disease ( 32581359) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Mean corpuscular hemoglobin ( 32888494) Nickel levels ( 26025379) Obesity-related traits ( 23251661) Periodontitis (Mean PAL) ( 24024966) QT interval (sulfonylurea treatment interaction) ( 27958378) Rhegmatogenous retinal detachment ( 23585552) Systemic juvenile idiopathic arthritis ( 27927641) Toenail selenium levels ( 25343990)
Interacting Genes		27 interacting genes: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA ESR1 H3C1 HSPB1 KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 RAP1A SDCBP SIN3B SS18	9 interacting genes: EP300 FUS GRB2 H3-3A MLLT10 NFKBID RBM14 SMARCA2 SMARCA4
Entrez ID		6595	6760
HPRD ID		02483	02559
Ensembl ID		ENSG00000080503	ENSG00000141380
Uniprot IDs		B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1	A0A024RC40 B4DLD3 B4DR34 B4E2J6 Q15532 Q4VAX0
PDB IDs		2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ
Enriched GO Terms of Interacting Partners?
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