SLIT1 and KRTAP13-2

Data Source:
BioGRID (two hybrid)

		SLIT1	KRTAP13-2
Description		slit guidance ligand 1	keratin associated protein 13-2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space	Cytosol Intermediate Filament
	Molecular Function	Calcium Ion Binding Protein Binding Heparin Binding Roundabout Binding	Protein Binding
	Biological Process	Nuclear Migration Axon Guidance Motor Neuron Axon Guidance Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Retinal Ganglion Cell Axon Guidance Dorsal/ventral Axon Guidance Axon Extension Involved In Axon Guidance Forebrain Morphogenesis Negative Chemotaxis Negative Regulation Of Synapse Assembly	Keratinization
Pathways		Netrin-1 signaling Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs	Keratinization
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Diastolic blood pressure (alcohol consumption interaction) ( 24376456) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Obesity-related traits ( 23251661)
Interacting Genes		16 interacting genes: ADAMTSL4 ATN1 CHRDL2 CYSRT1 FHL5 GPC1 HOXA1 KRTAP1-1 KRTAP10-8 KRTAP13-2 KRTAP13-3 MEOX2 MTNR1A ROBO1 TRIM42 ZNF620	80 interacting genes: ANAPC11 ANXA11 BCL6 C11orf1 C22orf39 CBFA2T2 CCDC125 CCDC24 CCDC57 CCNK CRYBA1 CSKMT CYSRT1 ENKD1 EPDR1 ETFDH FANCL FBXO17 FCHO1 GATA3 GEMIN4 GNE GPS2 GRN HNRNPH1 HOXA1 HR KCTD9 KLHL38 KPRP KRT3 KRTAP1-1 KRTAP10-5 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP15-1 KRTAP26-1 KRTAP3-1 KRTAP3-3 KRTAP4-4 KRTAP4-5 KRTAP9-2 MAGOHB MEOX2 MGAT5B NBPF19 NEK8 NHLRC4 NOTCH2NLA OIP5 OTX1 P4HB PATZ1 PHETA1 PITX1 POU2AF1 PPP1R32 RECK RHOXF2 SLC25A18 SLIT1 SMUG1 SNRPC SPEF1 SSC4D STK16 TCAF1 TEX37 TLE5 TNS2 TRAPPC6A TRIM68 TSPYL6 TSSK3 UNC5CL VGLL3 VWC2 YPEL3 ZIC1
Entrez ID		6585	337959
HPRD ID		04773	11201
Ensembl ID		ENSG00000187122	ENSG00000182816
Uniprot IDs		A6H8V1 O75093	Q52LG2
PDB IDs
Enriched GO Terms of Interacting Partners?
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