UBE2Z and RAPSN

Data Source:
BioGRID (two hybrid)

		UBE2Z	RAPSN
Description		ubiquitin conjugating enzyme E2 Z	receptor associated protein of the synapse
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Golgi Apparatus Centrosome Cytosol Plasma Membrane Neuromuscular Junction Postsynaptic Specialization Membrane
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuromuscular Synaptic Transmission Regulation Of Postsynaptic Membrane Organization Establishment Of Protein Localization To Postsynaptic Membrane
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)	Alcohol consumption (drinks per week) ( 30643258 30679032) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159) Diastolic blood pressure ( 28739976 27618452) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) Global electrical heterogeneity phenotypes ( 29622589) Height ( 28552196) Intraocular pressure ( 29617998 25173106 29235454) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Mood instability ( 31168069) Neuroticism ( 29255261) Red cell distribution width ( 32888494) Refractive error ( 32231278) Sleep duration (short sleep) ( 30846698) Systolic blood pressure ( 28739976 27618452) White blood cell count ( 29403010)
Interacting Genes		39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD	8 interacting genes: CHRNB1 DAG1 GRB2 KHDRBS1 KLHL8 MUSK TRIM54 UBE2Z
Entrez ID		65264	5913
HPRD ID		08589	03353
Ensembl ID		ENSG00000159202	ENSG00000165917
Uniprot IDs		Q9H832	A0A0S2Z4A2 A0A0S2Z4A6 A0A0S2Z4F8 A0A0S2Z4M9 Q13702
PDB IDs		5A4P
Enriched GO Terms of Interacting Partners?
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