UBE2Z and RNF139

Data Source:
BioGRID (two hybrid)

		UBE2Z	RNF139
Description		ubiquitin conjugating enzyme E2 Z	ring finger protein 139
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Integral Component Of Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protease Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin-like Protein Transferase Activity Signaling Receptor Activity Ubiquitin Protein Ligase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process	Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Negative Regulation Of Translation Protein Phosphopantetheinylation Protein Destabilization ERAD Pathway Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Processing Endoplasmic Reticulum Mannose Trimming Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Height ( 31562340) Myocardial infarction ( 26343387) Platelet count ( 32888494) Plateletcrit ( 32888494) Type 2 diabetes ( 30054458 29358691)
Interacting Genes		39 interacting genes: AK8 BMPR1B CCT3 DZIP3 GORASP2 HLTF HMBOX1 INCA1 LNX2 LPL MDM2 OTUB1 PLEKHA6 PLEKHF2 PPP1CA PRKN RAPSN REL RNF103 RNF130 RNF139 RNF144B RNF150 RNF166 RNF41 RNF5 SMAD1 SMAD4 SRA1 SYVN1 TGFBR1 TRAIP TRIM27 TRIM3 TRIM46 TRIM65 UBA1 UBA6 UBD	6 interacting genes: COPS5 EIF3A UBE2H UBE2U UBE2Z VHL
Entrez ID		65264	11236
HPRD ID		08589	04333
Ensembl ID		ENSG00000159202	ENSG00000170881
Uniprot IDs		Q9H832	Q8WU17
PDB IDs		5A4P
Enriched GO Terms of Interacting Partners?
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