SLC2A4 and HADH

Data Source:
HPRD (in vitro, two hybrid)

		SLC2A4	HADH
Description		solute carrier family 2 member 4	hydroxyacyl-CoA dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Sarcoplasmic Reticulum Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Cytoplasmic Vesicle Membrane Insulin-responsive Compartment Sarcolemma Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity	3-hydroxyacyl-CoA Dehydrogenase Activity Transferase Activity Identical Protein Binding NAD+ Binding
	Biological Process	Carbohydrate Metabolic Process Learning Or Memory Short-term Memory Long-term Memory Amylopectin Biosynthetic Process Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Cellular Response To Insulin Stimulus Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Response To Ethanol Glucose Import Brown Fat Cell Differentiation Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Osmotic Stress Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Transport Across Blood-brain Barrier Glucose Transmembrane Transport	Fatty Acid Beta-oxidation Regulation Of Insulin Secretion Positive Regulation Of Cold-induced Thermogenesis
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Cellular hexose transport Transcriptional regulation of white adipocyte differentiation	Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs			NADH Acetoacetyl-CoA 3-Hydroxybutyryl-Coenzyme A Omega-3-carboxylic acids
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Apolipoprotein B levels ( 32203549) Birth weight ( 23202124 31043758) Diastolic blood pressure ( 28135244) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Medication use (diuretics) ( 31015401) Metabolite levels ( 22286219) Offspring birth weight ( 31043758) Pulse pressure ( 28135244) Systolic blood pressure ( 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		40 interacting genes: ACOX1 ACTN1 ACTN4 AKT2 AP1M1 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CREB3 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N	8 interacting genes: ADH1A APP CDC42 CLK1 FBXL17 FBXO7 SLC2A4 STAT1
Entrez ID		6517	3033
HPRD ID		00688	08372
Ensembl ID		ENSG00000181856	ENSG00000138796
Uniprot IDs		P14672	A0A140VK76 B3KTT6 Q16836
PDB IDs			1F0Y 1F12 1F14 1F17 1IL0 1LSJ 1LSO 1M75 1M76 2HDH 3HAD 3RQS
Enriched GO Terms of Interacting Partners?
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