UPF3A and RBM8A

Data Source:
HPRD (in vivo)

		UPF3A	RBM8A
Description		UPF3A regulator of nonsense mediated mRNA decay	RNA binding motif protein 8A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding Structural Constituent Of Nuclear Pore Telomeric DNA Binding	RNA Binding MRNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleocytoplasmic Transport Positive Regulation Of Translation MRNA Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus Regulation Of Translation RNA Splicing MRNA 3'-end Processing
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Height ( 31562340) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)
Interacting Genes		9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1	20 interacting genes: APP CDC42 DPH1 EIF4A3 FBXO25 IKBKG IPO13 KAT2B MAGOH MAGOHB MCM7 NXF1 RNPS1 SF3B2 SRPK1 SRPK2 TCF12 TOE1 UPF3A UPF3B
Entrez ID		65110	9939
HPRD ID		09274	05609
Ensembl ID		ENSG00000169062	ENSG00000265241
Uniprot IDs		B3KUE7 Q9H1J1	A0A023T787 Q9Y5S9
PDB IDs		2L08	1P27 2HYI 2J0Q 2J0S 2XB2 3EX7 5XJC 5YZG 6ICZ 6QDV 7A5P
Enriched GO Terms of Interacting Partners?
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