UPF3A and ALYREF

Data Source:
HPRD (in vivo)

		UPF3A	ALYREF
Description		UPF3A regulator of nonsense mediated mRNA decay	Aly/REF export factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex Intracellular Membrane-bounded Organelle	Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding Structural Constituent Of Nuclear Pore Telomeric DNA Binding	RNA Binding Protein Binding C5-methylcytidine-containing RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nucleocytoplasmic Transport Positive Regulation Of Translation MRNA Transport	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Export From Nucleus MRNA Export From Nucleus Viral Process MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Height ( 31562340) Nodular sclerosis Hodgkin lymphoma ( 29196614) Pulse pressure ( 30578418)
Interacting Genes		9 interacting genes: ALYREF APP GSK3B IFITM2 NXF1 PIGT RBM8A SMG1 UPF1	11 interacting genes: AKT1 DDX39B ESR1 IL7R LEF1 MAGOH NXF1 PTEN RUNX2 THOC6 UPF3A
Entrez ID		65110	10189
HPRD ID		09274	09168
Ensembl ID		ENSG00000169062	ENSG00000183684
Uniprot IDs		B3KUE7 Q9H1J1	E9PB61 Q86V81
PDB IDs		2L08	3ULH
Enriched GO Terms of Interacting Partners?
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