TMEM237 and PRNP

Data Source:
BioGRID (pull down)

		TMEM237	PRNP
Description		transmembrane protein 237	prion protein
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane Photoreceptor Connecting Cilium Ciliary Transition Zone Cone Photoreceptor Outer Segment Rod Photoreceptor Outer Segment	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Cell Surface Postsynaptic Density Inclusion Body Extrinsic Component Of Membrane Dendrite Anchored Component Of External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Postsynapse
	Molecular Function	Protein Binding	Amyloid-beta Binding Protease Binding Copper Ion Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Microtubule Binding Tubulin Binding Aspartic-type Endopeptidase Inhibitor Activity Type 5 Metabotropic Glutamate Receptor Binding Type 8 Metabotropic Glutamate Receptor Binding Signaling Receptor Activity Identical Protein Binding Protein-containing Complex Binding Cuprous Ion Binding
	Biological Process	Regulation Of Wnt Signaling Pathway Cilium Assembly	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Learning Or Memory Long-term Memory Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Protein Destabilization Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Calcium-mediated Signaling Using Intracellular Calcium Source Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Activated T Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Positive Regulation Of Protein Targeting To Membrane Modulation Of Age-related Behavioral Decline Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Neuron Death Negative Regulation Of Amyloid-beta Formation Regulation Of Intracellular Calcium Activated Chloride Channel Activity Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Response To Amyloid-beta Cellular Response To Amyloid-beta Regulation Of Calcium Ion Import Across Plasma Membrane Neuron Projection Maintenance
Pathways			NCAM1 interactions Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			Tetracycline Copper
Diseases			Prion diseases; Creutzfeldt-Jacob disease (CJD); Gerstmann-Straussler disease (GSD); Gerstmann-Straussler-Scheinker disease (GSSD); Fatal familial insomnia (FFI)
GWAS		Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730)	Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (sporadic) ( 32949544 25918841) Creutzfeldt-Jakob disease (variant) ( 22137330) KANNO antigen negativity ( 31020675) Platelet aggregation ( 20526338) Prion diseases ( 22210626) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI (smoking interaction) ( 28443625)
Interacting Genes		122 interacting genes: ABHD16A ADAM33 ADIPOQ APOD APOL3 AQP1 ATP13A1 BET1 BLCAP BNIP2 BTN2A2 C1GALT1 C3orf52 C4orf3 CBLIF CCDC167 CD53 CDS1 CFHR5 CLDN4 CLN6 CNIH3 CTSA CXCL16 CXCL9 CYB5B EFNA5 EMC6 ERMP1 EXTL1 FBXO7 FKBP14 FXYD6 FZD7 GJB2 GKN2 GPR152 GPR25 GPR42 GRM2 GUCA2A GYPA IER3IP1 IFNGR1 IGFBP5 INSIG1 INSIG2 JAGN1 LAT LEPROTL1 LPAR3 LRP10 LTA MFF MFSD5 MFSD6 MS4A13 OPRD1 ORMDL3 OTOP2 OTOP3 PLPPR2 PNLIPRP1 POMGNT1 PRB1 PRNP RETREG3 RHD ROBO2 RPRM RUSF1 SEC22A SERP2 SERPINE1 SFXN5 SLC12A7 SLC16A4 SLC29A2 SLC2A5 SLC30A8 SLC35A4 SLC35B2 SLC35B4 SLC35E4 SLC35G1 SLC38A2 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC5A4 SLC7A1 SLC7A3 ST6GAL2 STRIT1 STX8 TLCD4 TM4SF19 TM6SF2 TMEFF2 TMEM107 TMEM11 TMEM128 TMEM144 TMEM147 TMEM179B TMEM201 TMEM254 TMEM42 TMEM60 TMEM72 TMEM86B TRARG1 UNC93A UNC93B1 UPK1B VAMP3 VEGFA YIPF6 ZFPL1	96 interacting genes: ABT1 ADAM23 ADAP2 ADRB2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 ATIC BAG6 BAZ2B C7orf50 CAV1 CCDC149 CCR1 CIRBP CLSTN1 CLU CNP CNTN1 CRYAB CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DOCK7 DPP6 DYRK3 ERI3 F2RL1 FAM27E3 FBLN5 FBXO45 FGF13 FHL1 FZD7 GRB2 HAX1 HSPA5 HSPD1 IER3 KIAA1191 KIFAP3 L1CAM LMNA LSAMP MAG MARK4 MMADHC MOG MTG1 NCAM1 NCAM2 NECTIN1 NHP2 NIPSNAP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PSMB5 PTAFR PTRH1 PYM1 RBM22 RNPC3 RPL41 SCNM1 SEC31A SPARCL1 STARD5 STIP1 SURF2 TBPL1 TMEM237 TRIM15 TSC22D4 TSLP TYMSOS UTP4 WDR5 WDR61 ZFYVE28 ZKSCAN8 ZNF408 ZNF740
Entrez ID		65062	5621
HPRD ID		12448	01453
Ensembl ID		ENSG00000155755	ENSG00000171867
Uniprot IDs		Q96Q45	F7VJQ1 P04156 Q53YK7
PDB IDs			1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I 4KML 4N9O 5L6R 5YJ4 5YJ5 6DU9 6LNI 6PQ5 6PQA 6SUZ 6SV2 6UUR
Enriched GO Terms of Interacting Partners?
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