PINK1 and CRLS1

Data Source:
BioGRID (pull down)

		PINK1	CRLS1
Description		PTEN induced kinase 1	cardiolipin synthase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cytosol Cytoskeleton Membrane Axon Growth Cone Integral Component Of Mitochondrial Outer Membrane Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Calcium-dependent Protein Kinase Activity Kinase Activity Peptidase Activator Activity Ubiquitin Protein Ligase Binding Protein Kinase B Binding Protein-containing Complex Binding C3HC4-type RING Finger Domain Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity TORC2 Complex Binding	1-acylglycerol-3-phosphate O-acyltransferase Activity Cardiolipin Synthase Activity CDP-diacylglycerol-phosphatidylglycerol Phosphatidyltransferase Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity
	Biological Process	Autophagy Of Mitochondrion Positive Regulation Of Protein Phosphorylation Regulation Of Oxidative Phosphorylation Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Positive Regulation Of Peptidase Activity Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Protein Ubiquitination Peptidyl-serine Phosphorylation Respiratory Electron Transport Chain Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Activation Of Protein Kinase B Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Dopamine Secretion Cellular Response To Oxidative Stress Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Peptidyl-serine Autophosphorylation TORC2 Signaling Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Negative Regulation Of JNK Cascade Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Hypoxia Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization Mitochondrion To Lysosome Transport Regulation Of Cellular Response To Oxidative Stress Positive Regulation Of Histone Deacetylase Activity Regulation Of Synaptic Vesicle Transport Negative Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Cristae Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Free Ubiquitin Chain Polymerization Positive Regulation Of NMDA Glutamate Receptor Activity Cellular Response To Hydrogen Sulfide Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Glycerophospholipid Biosynthetic Process Response To Thyroxine Response To Phosphatidylethanolamine
Pathways		PINK1-PRKN Mediated Mitophagy FOXO-mediated transcription of cell death genes	Acyl chain remodelling of PG Synthesis of CL
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		16 interacting genes: APPL2 BAG2 BAG5 CRLS1 DNM1L FBXO7 HSH2D MAP3K7 MARK2 NEAT1 PARK7 SNCAIP STAT3 TGM2 TRAF6 UBE2M	5 interacting genes: F2RL1 FBXO15 MCM6 MCM7 PINK1
Entrez ID		65018	54675
HPRD ID		10514	12187
Ensembl ID		ENSG00000158828	ENSG00000088766
Uniprot IDs		Q9BXM7	Q9UJA2
PDB IDs
Enriched GO Terms of Interacting Partners?
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