CRLS1 and MCM6

Data Source:
HPRD (in vivo)

		CRLS1	MCM6
Description		cardiolipin synthase 1	minichromosome maintenance complex component 6
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex CMG Complex
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Cardiolipin Synthase Activity CDP-diacylglycerol-phosphatidylglycerol Phosphatidyltransferase Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded 3'-5' DNA Helicase Activity
	Biological Process	Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Glycerophospholipid Biosynthetic Process Response To Thyroxine Response To Phosphatidylethanolamine	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication
Pathways		Acyl chain remodelling of PG Synthesis of CL	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Triglyceride levels x loop diuretics use interaction ( 31806883)	Body mass index ( 25673413) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		5 interacting genes: F2RL1 FBXO15 MCM6 MCM7 PINK1	38 interacting genes: C2CD6 CCNA1 CDC42 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 TRIM28 UBE3A ZBTB9
Entrez ID		54675	4175
HPRD ID		12187	03485
Ensembl ID		ENSG00000088766	ENSG00000076003
Uniprot IDs		Q9UJA2	Q14566
PDB IDs			2KLQ 2LE8 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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