CENPH and CENPK

Data Source:
BioGRID (two hybrid, two hybrid, affinity chromatography technology)

		CENPH	CENPK
Description		centromere protein H	centromere protein K
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol	Condensed Nuclear Chromosome Inner Kinetochore Nucleoplasm Cytosol
	Molecular Function	Protein Binding Kinetochore Binding	Protein Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation CENP-A Containing Nucleosome Assembly Kinetochore Assembly Kinetochore Organization	Mitotic Sister Chromatid Segregation CENP-A Containing Nucleosome Assembly Kinetochore Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS			Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: ABI2 C1orf216 C8orf58 CCDC146 CENPK DCTN2 ERH H2AP KIF2C LMNB1 MESD MTAP NDC80 NUF2 NUP54 RASSF4 SPAG5 ZNF493 ZSCAN12	11 interacting genes: AP1G2 CENPH HSPB1 MRFAP1L1 PCBD2 PEX14 RTN4IP1 SOX6 TRIM55 TRIM63 WASHC3
Entrez ID		64946	64105
HPRD ID		12029	13323
Ensembl ID		ENSG00000153044	ENSG00000123219
Uniprot IDs		A0A0S2Z5T0 Q9H3R5	D6RHD3 Q9BS16
PDB IDs
Enriched GO Terms of Interacting Partners?
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