NMNAT1 and TDO2

Data Source:
BioGRID (two hybrid, two hybrid)

		NMNAT1	TDO2
Description		nicotinamide nucleotide adenylyltransferase 1	tryptophan 2,3-dioxygenase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Cytosol
	Molecular Function	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Nucleotide Biosynthetic Process NAD Biosynthetic Process Response To Wounding NAD Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic DNA Fragmentation ATP Generation From Poly-ADP-D-ribose	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin
Pathways		Nicotinate metabolism	Tryptophan catabolism
Drugs		Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Resting heart rate ( 27798624)	Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)
Interacting Genes		19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2	20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26
Entrez ID		64802	6999
HPRD ID		16369	01847
Ensembl ID		ENSG00000173614	ENSG00000151790
Uniprot IDs		A0A024R4E1 B1AN62 Q9HAN9	P48775
PDB IDs		1GZU 1KKU 1KQN 1KQO 1KR2	4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6VBN
Enriched GO Terms of Interacting Partners?
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