NMNAT1 and FLOT2

Data Source:
BioGRID (two hybrid)

		NMNAT1	FLOT2
Description		nicotinamide nucleotide adenylyltransferase 1	flotillin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Uropod Endosome Plasma Membrane Caveola Adherens Junction Focal Adhesion Membrane Basolateral Plasma Membrane Apical Plasma Membrane Flotillin Complex Lamellipodium Endocytic Vesicle Cortical Actin Cytoskeleton Cytoplasmic Vesicle Vesicle Intracellular Membrane-bounded Organelle Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nicotinamide-nucleotide Adenylyltransferase Activity Nicotinate-nucleotide Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding
	Biological Process	Nucleotide Biosynthetic Process NAD Biosynthetic Process Response To Wounding NAD Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic DNA Fragmentation ATP Generation From Poly-ADP-D-ribose	Membrane Raft Assembly Cell Adhesion Epidermis Development Negative Regulation Of Gene Expression Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Toll-like Receptor 3 Signaling Pathway Protein Localization To Plasma Membrane Raft Regulation Of Myoblast Differentiation Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Plasma Membrane Negative Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Establishment Of T Cell Polarity
Pathways		Nicotinate metabolism	RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Synaptic adhesion-like molecules
Drugs		Nicotinamide Mononucleotide Deamido-Nad+
Diseases
GWAS		Resting heart rate ( 27798624)	Mean corpuscular hemoglobin ( 29403010) Red blood cell count ( 27863252)
Interacting Genes		19 interacting genes: APP BANP CCNC FLOT2 GORASP2 KPNA1 KPNA2 KPNA3 KPNA5 KPNA6 MSX1 NEK3 NFATC2IP NTRK2 PICK1 RNF4 SIK1 SIRT1 TDO2	11 interacting genes: APP CAV1 CAV2 DXO FLOT1 FYN HGS MAGEB4 NMNAT1 SPATA24 UBC
Entrez ID		64802	2319
HPRD ID		16369	00580
Ensembl ID		ENSG00000173614	ENSG00000132589
Uniprot IDs		A0A024R4E1 B1AN62 Q9HAN9	A0A024QZ62 J3QLD9 Q14254 Q6FG43 Q9BTI6
PDB IDs		1GZU 1KKU 1KQN 1KQO 1KR2
Enriched GO Terms of Interacting Partners?
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