BMI1 and TUSC3

Data Source:
BioGRID (pull down)

		BMI1	TUSC3
Description		BMI1 proto-oncogene, polycomb ring finger	tumor suppressor candidate 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex	Mitochondrion Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Oligosaccharyltransferase Complex
	Molecular Function	Protein Binding Zinc Ion Binding RING-like Zinc Finger Domain Binding Promoter-specific Chromatin Binding	Magnesium Ion Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Segment Specification Regulation Of Gene Expression Hemopoiesis Histone H2A-K119 Monoubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of G0 To G1 Transition	Protein N-linked Glycosylation Magnesium Ion Transport Protein N-linked Glycosylation Via Asparagine Cognition Transmembrane Transport Magnesium Ion Transmembrane Transport
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Asparagine N-linked glycosylation Miscellaneous transport and binding events Maturation of spike protein
Drugs
Diseases		Penile cancer	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Prostate-specific antigen levels ( 28139693)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Intelligence ( 22449649) Metabolite levels ( 23823483) Methamphetamine dependence ( 23594818) Prudent dietary pattern ( 28644415) Pulmonary function decline ( 22424883) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to SSRI in MDD or openness ( 29559929)
Interacting Genes		42 interacting genes: CASC9 CBX8 CEP126 CSNK2B E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16	2 interacting genes: BMI1 PPP1CA
Entrez ID		648	7991
HPRD ID		01277	03228
Ensembl ID		ENSG00000168283	ENSG00000104723
Uniprot IDs		P35226	Q13454
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6	4M8G 4M90 4M91 4M92
Enriched GO Terms of Interacting Partners?
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