BMI1 and MLLT1

Data Source:
BioGRID (pull down)

		BMI1	MLLT1
Description		BMI1 proto-oncogene, polycomb ring finger	MLLT1 super elongation complex subunit
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Nuclear Body PcG Protein Complex PRC1 Complex	Fibrillar Center Nucleoplasm Cytosol Transcription Elongation Factor Complex
	Molecular Function	Protein Binding Zinc Ion Binding RING-like Zinc Finger Domain Binding Promoter-specific Chromatin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Silencing Segment Specification Regulation Of Gene Expression Hemopoiesis Histone H2A-K119 Monoubiquitination Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of G0 To G1 Transition	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases		Penile cancer	Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Prostate-specific antigen levels ( 28139693)	Monocyte percentage of white cells ( 32888494) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)
Interacting Genes		42 interacting genes: CASC9 CBX8 CEP126 CSNK2B E2F6 FOXS1 H2AC18 H2AC20 H2AC4 H2AX H3-4 HSF2BP IMMT KAT5 KMT2A LRIF1 MAPK14 MLLT1 MUC1 NDEL1 PCBP2-OT1 PCGF3 PCGF6 PGR PHC1 PHC2 PTN RING1 RNF114 RNF2 RRM1 SOCS2 TRIM27 TUSC3 UBE2D2 UBE2D3 UBE2I USP11 USP15 VPS11 WHRN ZBTB16	12 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 H1-5 H3-4 MLLT10 PAF1 WDR5 YIF1A
Entrez ID		648	4298
HPRD ID		01277	15933
Ensembl ID		ENSG00000168283	ENSG00000130382
Uniprot IDs		P35226	Q03111
PDB IDs		2H0D 2NA1 3RPG 4R8P 5FR6	5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O
Enriched GO Terms of Interacting Partners?
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