SMURF2 and ACBD3

Data Source:
HPRD (two hybrid)

		SMURF2	ACBD3
Description		SMAD specific E3 ubiquitin protein ligase 2	acyl-CoA binding domain containing 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Membrane Raft	Golgi Membrane Mitochondrion Golgi Apparatus Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity	Fatty-acyl-CoA Binding Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Steroid Biosynthetic Process Viral Process
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)	Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)
Interacting Genes		91 interacting genes: ABRAXAS2 ACBD3 ACOX3 AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44	4 interacting genes: ERRFI1 GOLGB1 HMGB1 SMURF2
Entrez ID		64750	64746
HPRD ID		06901	08432
Ensembl ID		ENSG00000108854	ENSG00000182827
Uniprot IDs		Q96DE7 Q9HAU4	A0A024R3P9 Q9H3P7
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4	2N72 2N73 5LZ1 5LZ3 5LZ6 5TDQ 6HLN 6HLT 6HLV 6HLW 6HM8 6HMV
Enriched GO Terms of Interacting Partners?
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