SMURF2 and PDE4B

Data Source:
BioGRID (pull down)

		SMURF2	PDE4B
Description		SMAD specific E3 ubiquitin protein ligase 2	phosphodiesterase 4B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Membrane Raft	Gamma-tubulin Complex Nucleus Centrosome Cytosol Voltage-gated Calcium Channel Complex Synaptic Vesicle Postsynaptic Density Z Disc Dendritic Spine Perinuclear Region Of Cytoplasm Excitatory Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity CAMP Binding Gamma-tubulin Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration	Neutrophil Homeostasis CAMP Catabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Cellular Response To Drug T Cell Receptor Signaling Pathway Leukocyte Migration Cellular Response To Lipopolysaccharide Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Relaxation Of Cardiac Muscle
Pathways		Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	DARPP-32 events
Drugs			Adenosine phosphate Caffeine Caffeine Theophylline Dyphylline Enprofylline Iloprost Papaverine Theobromine Amrinone Daxalipram Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cilomilast (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Crisaborole Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
Diseases
GWAS		Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)	Acute lymphoblastic leukemia (childhood) ( 22076464 23007406) Adult body size ( 32376654) Age at voice drop ( 27182965) Alcohol consumption ( 31358974) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety and stress-related disorders ( 31116379) Anxiety and stress-related disorders (excluding adjustment disorder) ( 31116379) Anxiety and stress-related disorders (excluding co-morbid schizophrenia) ( 31116379) Anxiety and stress-related disorders (including obsessive-compulsive disorder) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity covariate model) ( 31116379) Anxiety and stress-related disorders (psychiatric co-morbidity weighting design) ( 31116379) Anxiety disorders ( 31116379) Birth weight ( 31043758) Body size at age 10 ( 32376654) Chronotype ( 30696823) Echocardiographic traits ( 17903301) Economic and political preferences (feminism/equality) ( 22566634) Fibrinogen levels ( 28107422) Gastroesophageal reflux disease ( 31527586) Low tan response ( 29739929) Multiple sclerosis ( 31604244) Phenylephrine infusion rate during anesthesia ( 31455332) Problematic alcohol use ( 32451486) QT interval ( 29213071) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Sleep duration (short sleep) ( 30846698) Smoking initiation ( 30617275) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Staphylococcus aureus infection ( 24847357) Stress-related disorders ( 31116379)
Interacting Genes		91 interacting genes: ABRAXAS2 ACBD3 ACOX3 AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FKBP4 FLNB FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RNF20 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44	5 interacting genes: DISC1 MAGEA11 PRKACA RCBTB2 SMURF2
Entrez ID		64750	5142
HPRD ID		06901	02528
Ensembl ID		ENSG00000108854	ENSG00000184588
Uniprot IDs		Q96DE7 Q9HAU4	Q07343 Q59GM8 Q68CX5 X5DNX5 X5DR82
PDB IDs		1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4	1F0J 1JP1 1JP2 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ 3HMV 3KKT 3LY2 3O0J 3O56 3O57 3W5E 3WD9 4KP6 4MYQ 4NW7 4WZI 4X0F 5K6J 5LAQ 5OHJ 6BOJ
Enriched GO Terms of Interacting Partners?
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