CLEC7A and TMPRSS4

Data Source:
BioGRID (two hybrid)

		CLEC7A	TMPRSS4
Description		C-type lectin domain containing 7A	transmembrane serine protease 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Space Plasma Membrane Integral Component Of Membrane Secretory Granule
	Molecular Function	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Metal Ion Binding	Serine-type Endopeptidase Activity Scavenger Receptor Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Leukocyte Activation Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Respiratory Burst Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation	Proteolysis Endocytosis Response To Wounding Regulation Of Gene Expression Protein Processing Negative Regulation Of Growth Rate Positive Regulation Of Viral Entry Into Host Cell
Pathways		CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Interacting Genes		47 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1	14 interacting genes: BNIP3L CLEC7A CLRN1 ERVFRD-1 FAM209A FNDC9 GPX8 KASH5 LMNA RASGRP4 SIGLEC12 SUSD3 SYNE4 TMEM79
Entrez ID		64581	56649
HPRD ID		08396	05952
Ensembl ID		ENSG00000172243	ENSG00000137648
Uniprot IDs		A0A024RAN9 A0A0S2Z5Q1 Q68D78 Q9BXN2	B7Z458 B7Z8X1 B7Z900 Q9NRS4
PDB IDs
Enriched GO Terms of Interacting Partners?
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