SGK1 and MAPKAP1

Data Source:
BioGRID (pull down)

		SGK1	MAPKAP1
Description		serum/glucocorticoid regulated kinase 1	MAPK associated protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Speck	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Vesicle TORC2 Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Small GTPase Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Cellular Response To Aldosterone	Substantia Nigra Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC2 Signaling Negative Regulation Of Ras Protein Signal Transduction Regulation Of Cellular Response To Oxidative Stress
Pathways		Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
Drugs		Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Body mass index ( 28892062) Diverticular disease ( 30177863) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (calcium channel blockers) ( 31015401) Raw vegetable consumption ( 32066663) Resting heart rate ( 27798624) Sleep duration ( 30531941) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		37 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C UBC	9 interacting genes: ABCB1 AKT1 CDC42EP1 ECI1 MAPK8 NRAS PRKCA SGK1 YWHAG
Entrez ID		6446	79109
HPRD ID		04264	17464
Ensembl ID		ENSG00000118515	ENSG00000119487
Uniprot IDs		B7Z325 E9PR89 O00141	A0A024R863 Q9BPZ7
PDB IDs		2R5T 3HDM 3HDN	3VOQ 5ZCS
Enriched GO Terms of Interacting Partners?
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