PALS1 and SOCS4

Data Source:
BioGRID (two hybrid)

		PALS1	SOCS4
Description		protein associated with LIN7 1, MAGUK family member	suppressor of cytokine signaling 4
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Apical Plasma Membrane Axon Protein-containing Complex Myelin Sheath Adaxonal Region Perikaryon Lateral Loop Schmidt-Lanterman Incisure Extracellular Exosome	Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Binding ATP Binding Protein Domain Specific Binding	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation
Pathways		Tight junction interactions	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
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GWAS
Interacting Genes		16 interacting genes: ARF6 BHLHB9 CRB3 DLGAP4 FTCD LIN7A LIN7B LIN7C MPP4 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2	11 interacting genes: CNMD EGFR LDHAL6B MDFIC NR4A1 PALS1 PLPP6 SPRY1 TEKT4 TNK2 VWF
Entrez ID		64398	122809
HPRD ID		09508	18084
Ensembl ID		ENSG00000072415	ENSG00000180008
Uniprot IDs		Q658X5 Q8N3R9	Q5H9R6 Q8WXH5
PDB IDs		1Y76 3UIT 4UU5 4UU6 4WSI	2IZV
Enriched GO Terms of Interacting Partners?
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