PALS1 and FTCD

Data Source:
BioGRID (two hybrid)

		PALS1	FTCD
Description		protein associated with LIN7 1, MAGUK family member	formimidoyltransferase cyclodeaminase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Apical Plasma Membrane Axon Protein-containing Complex Myelin Sheath Adaxonal Region Perikaryon Lateral Loop Schmidt-Lanterman Incisure Extracellular Exosome	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Protein Domain Specific Binding	Protein Binding Folic Acid Binding Microtubule Binding Formimidoyltransferase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Gene Expression Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane	Histidine Catabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization Histidine Catabolic Process To Glutamate And Formamide Histidine Catabolic Process To Glutamate And Formate Tetrahydrofolate Interconversion
Pathways		Tight junction interactions	Histidine catabolism
Drugs			Tetrahydrofolic acid Glutamic acid (6R)-Folinic acid
Diseases
GWAS			Blood protein levels ( 30072576) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: ARF6 BHLHB9 CRB3 DLGAP4 FTCD LIN7A LIN7B LIN7C MPP4 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2	5 interacting genes: CCDC183 HGS KASH5 MED4 PALS1
Entrez ID		64398	10841
HPRD ID		09508	08430
Ensembl ID		ENSG00000072415	ENSG00000160282
Uniprot IDs		Q658X5 Q8N3R9	O95954
PDB IDs		1Y76 3UIT 4UU5 4UU6 4WSI
Enriched GO Terms of Interacting Partners?
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