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GMCL1 and CUL3
Data Source:
BioGRID
(two hybrid, two hybrid, affinity chromatography technology)
GMCL1
CUL3
Description
germ cell-less 1, spermatogenesis associated
cullin 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Matrix
Golgi Membrane
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Polar Microtubule
Cytosol
Plasma Membrane
Membrane
Cullin-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Sperm Flagellum
Extracellular Exosome
Mitotic Spindle
Molecular Function
Protein Binding
Identical Protein Binding
Ubiquitin-protein Transferase Activity
Notch Binding
Protein Binding
Cyclin Binding
POZ Domain Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Protein Ligase Activity
Biological Process
Multicellular Organism Development
Germ Cell Development
Spermatogenesis
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Protein Polyubiquitination
Trophectodermal Cellular Morphogenesis
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Mitotic Metaphase Plate Congression
Integrin-mediated Signaling Pathway
Gastrulation
Positive Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Cell Migration
Protein Ubiquitination
Stem Cell Division
Cell Projection Organization
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Cytokinesis
Negative Regulation Of Rho Protein Signal Transduction
Embryonic Cleavage
Stress Fiber Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Fibroblast Apoptotic Process
Positive Regulation Of Mitotic Metaphase/anaphase Transition
COPII Vesicle Coating
Protein Autoubiquitination
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Liver Morphogenesis
Negative Regulation Of Canonical Wnt Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Degradation of DVL
Hedgehog 'on' state
Regulation of RAS by GAPs
Neddylation
RHOBTB2 GTPase cycle
RHOBTB1 GTPase cycle
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Atrial fibrillation (
28416818
30061737
29892015
)
Colorectal or endometrial cancer (
26621817
)
Red cell distribution width (
32888494
)
Whole brain grey matter density (
31530798
)
Acute graft versus host disease in bone marrow transplantation (recipient effect) (
27595289
)
General risk tolerance (MTAG) (
30643258
)
Response to bupropion and depression (
27622933
)
Schizophrenia (
28991256
25056061
29483656
30285260
)
Sensorimotor dexterity (
31596458
)
Thrombin-activatable fibrinolysis inhibitor activation peptide (
29378355
)
Interacting Genes
99 interacting genes:
APLF
APOL6
AXIN1
BEGAIN
BSCL2
BYSL
C5orf60
CCDC13
CCDC25
CDC37
CFAP410
CHIC2
CIB3
CLK2
CUL3
EHHADH
ELOA
EMD
EXOC3
FAM167A
FAM50B
FKBP1B
FLYWCH1
FOSL2
FOXR1
FRMD6
GAGE1
GAGE10
GAGE12B
GAGE12G
GAGE12I
GAGE12J
GAGE2A
GAGE2C
GAGE2E
GAGE5
GLRX3
GMCL2
GOLGA2
GRAMD1A
HYKK
IL17F
KANK2
KAT5
KIFC3
KPNA2
KRT75
LNX1
MID1
MID2
MINDY1
MORF4L1
MPPE1
MTRR
MYLIP
MYO5B
NEBL
NFIL3
NTAQ1
NUMA1
PARD6B
PARP16
PAX4
PBXIP1
PIBF1
PIH1D2
PPP1R18
PTPN7
QRICH1
RAD54B
RANBP3
RASA1
RNF4
RNMT
SHQ1
SLC15A3
SNX20
STK3
SUMO1
SUMO1P1
SYT17
SYT6
TBC1D1
TLK2
TMPO
TRIM13
TRIM21
TRIM38
TRIM54
TSG101
TSSC4
UBE2I
XAGE2
XAGE3
YY1
ZBTB24
ZMYM2
ZNF23
ZNF250
78 interacting genes:
ABTB1
ABTB2
ACLY
APP
ARHGEF12
BTBD1
BTBD10
BTBD2
BTBD3
BTBD6
CAMK1D
CAND1
CCND1
CCNE1
CDC25A
CDC34
CLK1
COMMD1
COPS5
DCUN1D2
DCUN1D3
DCUN1D4
DCUN1D5
DYRK4
EFNB1
ELOC
FOLR1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GPS1
HLA-DMB
HSF2
KCTD10
KCTD11
KCTD13
KCTD17
KCTD5
KCTD6
KCTD7
KCTD9
KEAP1
KLHL12
KLHL2
KLHL3
KLHL42
MAP1LC3B
MAP1LC3C
MAT2A
MTNR1A
MTNR1B
NEDD8
OLIG2
PDCD6
PDIA2
PEF1
RBBP8
RBX1
RCBTB1
RCBTB2
RHOBTB3
RIT1
RNF7
SHKBP1
SPOP
SUMO2
SUMO3
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2E1
UBE2E2
UBE2E3
UBE2R2
WNT7B
ZMAT4
Entrez ID
64395
8452
HPRD ID
13587
09123
Ensembl ID
ENSG00000087338
ENSG00000036257
Uniprot IDs
Q53SE7
Q96IK5
A0A024R475
B7Z600
Q13618
PDB IDs
2MYL
2MYM
4AP2
4APF
4EOZ
4HXI
5NLB
6I2M
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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