KCNJ4 and LIN7B

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		KCNJ4	LIN7B
Description		potassium inwardly rectifying channel subfamily J member 4	lin-7 homolog B, crumbs cell polarity complex component
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Postsynaptic Membrane	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding	Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Cardiac Conduction Potassium Ion Import Across Plasma Membrane	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Ranolazine Miconazole Carvedilol Dronedarone
Diseases
GWAS		Automobile speeding propensity ( 30643258) Chronotype ( 30696823) Conotruncal heart defects ( 24800985) TPE interval (resting) ( 32386560)
Interacting Genes		11 interacting genes: CASK DLG1 DLG2 DLG4 GNGT2 GPR35 IL16 KCNJ2 LIN7B PRKCD SNTA1	22 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP2 MPP3 MPP7 NTAQ1 PALS1 PALS2 PSMB1 TCEANC TRAPPC12
Entrez ID		3761	64130
HPRD ID		02738	10040
Ensembl ID		ENSG00000168135	ENSG00000104863
Uniprot IDs		A0A024R1L8 P48050 Q58F07	Q9HAP6
PDB IDs		3GJ9	2DKR
Enriched GO Terms of Interacting Partners?
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