SELE and ACTA2

Data Source:
BioGRID (pull down)

		SELE	ACTA2
Description		selectin E	actin alpha 2, smooth muscle
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Extracellular Space Cytoplasm Cytosol Dynactin Complex Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding	ATP Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Migration Leukocyte Tethering Or Rolling Response To Interleukin-1 Positive Regulation Of Leukocyte Tethering Or Rolling	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration
Pathways		Cell surface interactions at the vascular wall	Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Carvedilol N-acetyl-alpha-neuraminic acid Endostatin	Phenethyl Isothiocyanate
Diseases			Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte percentage of white cells ( 32888494)	Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)
Interacting Genes		15 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 TRIM54 VCL	18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1
Entrez ID		6401	59
HPRD ID		00566	00031
Ensembl ID		ENSG00000007908	ENSG00000107796
Uniprot IDs		P16581	D2JYH4 P62736
PDB IDs		1ESL 1G1T 1KJA 4C16 4CSY 6EYI 6EYJ 6EYK
Enriched GO Terms of Interacting Partners?
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