ACTA2 and DNASE1

Data Source:
HPRD (in vitro)

		ACTA2	DNASE1
Description		actin alpha 2, smooth muscle	deoxyribonuclease 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome	Extracellular Region Nucleus Nuclear Envelope Extracellular Exosome
	Molecular Function	ATP Binding Protein Kinase Binding	DNA Binding Actin Binding Deoxyribonuclease I Activity Protein Binding
	Biological Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration	DNA Catabolic Process, Endonucleolytic Neutrophil Activation Involved In Immune Response Regulation Of Acute Inflammatory Response DNA Catabolic Process Apoptotic Process Regulation Of Neutrophil Mediated Cytotoxicity
Pathways		Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription
Drugs		Phenethyl Isothiocyanate
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)	Body mass index ( 29273807) Monocyte percentage of white cells ( 32888494)
Interacting Genes		18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1	4 interacting genes: ACTA1 ACTA2 ACTB ACTG1
Entrez ID		59	1773
HPRD ID		00031	00509
Ensembl ID		ENSG00000107796	ENSG00000213918
Uniprot IDs		D2JYH4 P62736	P24855
PDB IDs			4AWN
Enriched GO Terms of Interacting Partners?
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