BLK and GRB10

Data Source:
BioGRID (two hybrid)

		BLK	GRB10
Description		BLK proto-oncogene, Src family tyrosine kinase	growth factor receptor bound protein 10
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Insulin Receptor Binding Protein Binding
	Biological Process	Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Platelet Degranulation Regulation Of B Cell Apoptotic Process Cellular Response To DNA Damage Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Negative Regulation Of B Cell Proliferation Neuron Projection Development Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Regulation Of Mast Cell Degranulation Innate Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Mast Cell Proliferation Regulation Of Platelet Aggregation Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Apoptotic Process	Axon Guidance Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling FLT3 Signaling Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Fostamatinib Zanubrutinib
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Albumin-globulin ratio ( 29403010) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 33106546 22446962) Neurofibrillary tangles ( 31497858) Non-albumin protein levels ( 29403010) Number of sexual partners ( 30643258) Periodontitis (CDC/AAP) ( 24024966) Phosphatidylcholine levels ( 31551469) Polymyositis ( 26362759) Processed meat consumption ( 32066663) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 21452313 30423114 23143596 24390342 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 23053960 26316170 26502338 18204098 21408207 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 30572963 29293537) Systolic blood pressure ( 28135244 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Acute lymphoblastic leukemia (childhood) ( 23512250) Area under the curve of insulin levels ( 24699409) Birth weight ( 31043758) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Corpus callosum mid-anterior volume ( 31530798) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Diastolic blood pressure ( 30224653) Eosinophil counts ( 32888494 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Femoral neck bone mineral density ( 22504420) Fractures ( 30158200) Heel bone mineral density ( 30598549) Incremental insulin ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Ratio of the area under the curve for insulin and the area under the curve for glucose ( 24699409) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia (treatment resistant) ( 25223841) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 21779181) Total body bone mineral density ( 29304378)
Interacting Genes		50 interacting genes: AR BCAS2 BCL2 BCL2L1 BCR BIRC2 CBL CCDC33 CD79A CD79B CRKL CTR9 EFS EGFR ERBB2 ERBB3 ERBB4 FBXO7 FCGR2A FCGR2B FLACC1 FXR1 FXR2 GAB1 GRB10 HSF2BP IKZF3 JAKMIP1 KIT MET MID2 PICK1 PIK3R1 PIK3R3 PLCG2 PXN SH2D1B SKAP2 SLA SOCS3 SSBP3 STAP2 STAT3 TDP2 UBE3A ZBTB32 ZBTB42 ZBTB8A ZMAT1 ZNF774	48 interacting genes: AANAT ABL1 AKT1 APP BAIAP2 BCR BLK CHFR CNOT9 DOK1 EGFR ELK1 EPHB1 ERBB2 ERBB4 FARS2 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KANK2 KDR KIT KPNA3 MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NFKBID NOA1 PDGFRB PICK1 RAF1 RET SRC TEKT4 TEPSIN TNK1 TRIM55 TRIM63 TXK ZDHHC17 ZMYND19
Entrez ID		640	2887
HPRD ID		01866	03312
Ensembl ID		ENSG00000136573	ENSG00000106070
Uniprot IDs		E9PJX5 P51451 Q05D26	Q13322
PDB IDs			1NRV 3HK0
Enriched GO Terms of Interacting Partners?
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