BLK and ZNF774

Data Source:
BioGRID (two hybrid)

		BLK	ZNF774
Description		BLK proto-oncogene, Src family tyrosine kinase	zinc finger protein 774
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleus
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Fc Receptor Mediated Stimulatory Signaling Pathway Tolerance Induction To Self Antigen Platelet Degranulation Regulation Of B Cell Apoptotic Process Cellular Response To DNA Damage Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation Negative Regulation Of B Cell Proliferation Neuron Projection Development Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Regulation Of Mast Cell Degranulation Innate Immune Response B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Mast Cell Proliferation Regulation Of Platelet Aggregation Dendritic Cell Differentiation Positive Regulation Of Dendritic Cell Apoptotic Process	Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX1 regulates transcription of genes involved in BCR signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Generic Transcription Pathway
Drugs		Fostamatinib Zanubrutinib
Diseases		Maturity onset diabetes of the young (MODY)
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Albumin-globulin ratio ( 29403010) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 27841878 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Estimated glomerular filtration rate ( 31152163) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Immune response to smallpox vaccine (IL-6) ( 22610502) Kawasaki disease ( 22446961 33106546 22446962) Neurofibrillary tangles ( 31497858) Non-albumin protein levels ( 29403010) Number of sexual partners ( 30643258) Periodontitis (CDC/AAP) ( 24024966) Phosphatidylcholine levels ( 31551469) Polymyositis ( 26362759) Processed meat consumption ( 32066663) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 21452313 30423114 23143596 24390342 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 27399966 23273568 26663301 23053960 26316170 26502338 18204098 21408207 19165918 28714469 19838193 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 31672989 30572963 29293537) Systolic blood pressure ( 28135244 27841878 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Male-pattern baldness ( 28196072) Rheumatoid arthritis ( 22446963)
Interacting Genes		50 interacting genes: AR BCAS2 BCL2 BCL2L1 BCR BIRC2 CBL CCDC33 CD79A CD79B CRKL CTR9 EFS EGFR ERBB2 ERBB3 ERBB4 FBXO7 FCGR2A FCGR2B FLACC1 FXR1 FXR2 GAB1 GRB10 HSF2BP IKZF3 JAKMIP1 KIT MET MID2 PICK1 PIK3R1 PIK3R3 PLCG2 PXN SH2D1B SKAP2 SLA SOCS3 SSBP3 STAP2 STAT3 TDP2 UBE3A ZBTB32 ZBTB42 ZBTB8A ZMAT1 ZNF774	77 interacting genes: BACH2 BEGAIN BLK BOLA2 BOLA2B CABP2 CALCOCO2 CARD9 CATSPER1 CCDC102B CCDC130 CCDC136 CCDC6 CCHCR1 CDK18 CDKN2D CEP63 CIB3 COL8A1 CPNE7 DTX2 DVL3 EFEMP2 EMD FAM124B FSD2 GABARAPL2 GEM GFAP GLRX3 GOLGA1 GOLGA2 GTPBP3 GYS1 GZMM HOXA1 HOXB5 HSF2BP IL16 IPO8 KANK2 KIFC3 KRTAP10-6 KRTAP10-7 KRTAP10-9 KRTAP4-5 LDOC1 LONRF1 MAGOHB MID2 MLH1 MTUS2 MYO15B NDOR1 NEK6 NID2 PIBF1 PICK1 PRPF31 PSMB1 RABEP1 RAD51D RBM11 SCNM1 SH2D4A SMAD3 STK16 TRAF2 TSTD2 USP49 VWC2 ZNF165 ZNF417 ZNF48 ZNF526 ZNF572 ZNF587
Entrez ID		640	342132
HPRD ID		01866	17571
Ensembl ID		ENSG00000136573	ENSG00000196391
Uniprot IDs		E9PJX5 P51451 Q05D26	Q6NX45
PDB IDs
Enriched GO Terms of Interacting Partners?
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