TRAPPC2 and EIF3C

Data Source:
BioGRID (two hybrid)

		TRAPPC2	EIF3C
Description		trafficking protein particle complex subunit 2	eukaryotic translation initiation factor 3 subunit C
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol TRAPP Complex Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Protein Binding Transcription Factor Binding Ion Channel Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	Skeletal System Development Regulation Of Transcription, DNA-templated Endoplasmic Reticulum To Golgi Vesicle-mediated Transport COPII Vesicle Coating	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases		Spondyloepiphyseal dysplasia tarda
GWAS			Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)
Interacting Genes		37 interacting genes: ABRA CLIC1 CLIC2 DAPK1 EIF3C ENO1 ENO3 EPS15L1 HLA-E INCA1 JOSD2 KCTD1 LSM3 MBD3L1 MFHAS1 NICN1 NME4 NR5A1 PITX1 PYGM REPS1 SLC25A35 SNAPC5 TEPSIN TRAPPC3 TRAPPC3L TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC9 UQCC2 ZBED1 ZBTB38 ZNF438 ZNF655 ZRANB1	19 interacting genes: AAGAB ALKBH4 CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 NDUFA4L2 PFDN1 PLEKHF2 RPS6KA3 SMAD9 SNIP1 TACC3 TRAPPC2
Entrez ID		6399	8663
HPRD ID		02189	04889
Ensembl ID		ENSG00000196459	ENSG00000184110
Uniprot IDs		P0DI81 P0DI82 Q6IBE5	A0A024QYU9 Q99613
PDB IDs			3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09
Enriched GO Terms of Interacting Partners?
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