FIGNL1 and IDH1

Data Source:
BioGRID (two hybrid)

		FIGNL1	IDH1
Description		fidgetin like 1	isocitrate dehydrogenase (NADP(+)) 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Microtubule-severing ATPase Activity Hydrolase Activity ATPase Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding NADP Binding NAD Binding
	Biological Process	Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Cytoplasmic Microtubule Organization Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Protein Targeting To Peroxisome NADP Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Neutrophil Degranulation Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways			Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import
Drugs			Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)	Adult diffuse glioma (IDH mutation) ( 32386320) Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		8 interacting genes: C1orf112 DMC1 GCC1 IDH1 ITGB1BP1 KDM1A RAD51 SPIDR	16 interacting genes: AGGF1 CALM1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 LAX1 LINC01554 NUP62 PEX5 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		63979	3417
HPRD ID		10958	00984
Ensembl ID		ENSG00000132436	ENSG00000138413
Uniprot IDs		B3KNH6 Q6PIW4	A0A024R3Y6 O75874
PDB IDs		3D8B	1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F 6U4J 6VEI 6VG0
Enriched GO Terms of Interacting Partners?
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