RNF123 and LMNB1

Data Source:
BioGRID (enzymatic study)

		RNF123	LMNB1
Description		ring finger protein 123	lamin B1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Membrane	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Matrix Nuclear Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Metal Ion Binding	Structural Molecule Activity Protein Binding Phospholipase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Ubiquitination Protein Deubiquitination Proteolysis Involved In Cellular Protein Catabolic Process	Interleukin-12-mediated Signaling Pathway
Pathways		Ub-specific processing proteases Antigen processing: Ubiquitination & Proteasome degradation	Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Blood protein levels ( 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income ( 31844048) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Multisite chronic pain ( 31194737) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576 29875488) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		14 interacting genes: CDKN1B EMD LMNA LMNB1 MTDH RB1 SMAD2 SMAD9 TMPO UBAC1 UBC UBE2D1 UBE2D2 UBE2W	44 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA1 KPNA5 KPNA6 LBR LMNA LMNB2 M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ
Entrez ID		63891	4001
HPRD ID		11499	01036
Ensembl ID		ENSG00000164068	ENSG00000113368
Uniprot IDs		Q5XPI4	B4DZT3 P20700
PDB IDs		2MA6	2KPW 3JT0 3TYY 3UMN 5VVX
Enriched GO Terms of Interacting Partners?
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