LMNB1 and PRPH

Data Source:
HPRD (in vitro)

		LMNB1	PRPH
Description		lamin B1	peripherin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Matrix Nuclear Membrane	Cytoplasm Intermediate Filament Membrane Axon Perikaryon Type III Intermediate Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Phospholipase Binding Sequence-specific Double-stranded DNA Binding	Structural Molecule Activity Protein Binding
	Biological Process	Interleukin-12-mediated Signaling Pathway	Intermediate Filament Cytoskeleton Organization
Pathways		Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS		Blood protein levels ( 30072576 29875488) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)	Prostate cancer ( 21743467) Sural nerve amplitude potential ( 30992453)
Interacting Genes		44 interacting genes: ABCG8 ATF4 CASP3 CASP6 CCDC88B CDK1 CENPH DMAP1 FAM169A GABARAP GIT2 GZMA GZMB KPNA1 KPNA5 KPNA6 LBR LMNA LMNB2 M1AP MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PIH1D2 PLEC PPP1R13B PRKCA PRKCB PRKCD PRPH PTEN RNF123 SERPINA3 SNAPIN SRPK2 SUMO4 TMPO TOR1AIP1 TP53BP2 UBE2I URB2 YWHAQ	36 interacting genes: CDC37 CT55 DDX6 DES FCHO1 INCA1 KIFC3 KRT14 KRT15 KRT16 KRT19 KRT20 KRT24 KRT27 KRT31 KRT75 LCA5L LENG1 LMNB1 LNX1 MAGOHB MYO5A NXF1 PIAS2 PPP1R13B PPP1R18 PRKAA2 PRPH2 PSMA1 TCEA2 TCP10L TTC23 VIM ZC4H2 ZMAT2 ZNF572
Entrez ID		4001	5630
HPRD ID		01036	01365
Ensembl ID		ENSG00000113368	ENSG00000135406
Uniprot IDs		B4DZT3 P20700	B3KWQ6 P41219
PDB IDs		2KPW 3JT0 3TYY 3UMN 5VVX
Enriched GO Terms of Interacting Partners?
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