CXCL12 and CCL25

CXCL12

CCL25

Description C-X-C motif chemokine ligand 12 C-C motif chemokine ligand 25
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
  • Blood protein levels ( 30072576)
  • Body mass index ( 25760438)
  • Coronary artery disease ( 32469254 26708285 24262325 26343387)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Coronary heart disease ( 17634449 21378990)
  • Diastolic blood pressure ( 27841878)
  • Eosinophil counts ( 32888494)
  • Eosinophil percentage of white cells ( 32888494)
  • Granulocyte count ( 27863252)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676)
  • Lymphocyte counts ( 32888494)
  • Monocyte count ( 32888494 27863252)
  • Myeloid white cell count ( 27863252)
  • Myocardial infarction ( 26343387)
  • Myocardial infarction (early onset) ( 19198609)
  • Neutrophil count ( 32888494 27863252)
  • QT interval (ambient particulate matter interaction) ( 28749367)
  • Red blood cell count ( 32888494)
  • Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665)
  • Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
  • Schizophrenia ( 23212062)
  • Smoking initiation (ever regular vs never regular) ( 31089300)
  • Sum basophil neutrophil counts ( 27863252)
  • Sum neutrophil eosinophil counts ( 27863252)
  • White blood cell count ( 32888494 27863252)
Interacting Genes 30 interacting genes: CCL11 CCL13 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CD4 CTSG CXCL10 CXCL11 CXCL14 CXCL17 CXCL2 CXCL6 CXCL9 CXCR4 DAZAP2 DPP4 ELANE FBXO7 FN1 MMP2 PF4 PF4V1 PPBP VCAN XCL1 XCL2 11 interacting genes: ACKR2 ACKR4 CCL17 CCL5 CCR10 CCR9 CXCL11 CXCL12 CXCL17 PF4 PF4V1
Entrez ID 6387 6370
HPRD ID 02904 03976
Ensembl ID ENSG00000107562 ENSG00000131142
Uniprot IDs P48061 O15444
PDB IDs 1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2N55 2NWG 2SDF 3GV3 3HP3 4LMQ 4UAI 6SHR
Enriched GO Terms of Interacting Partners?
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