CXCL12 and PPBP

CXCL12

PPBP

Description C-X-C motif chemokine ligand 12 pro-platelet basic protein
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GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Anti-drug antibodies in autoimmune disease (time to event) ( 33125391)
  • Blood protein levels ( 30072576)
  • Body mass index ( 25760438)
  • Coronary artery disease ( 32469254 26708285 24262325 26343387)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Coronary heart disease ( 17634449 21378990)
  • Diastolic blood pressure ( 27841878)
  • Eosinophil counts ( 32888494)
  • Eosinophil percentage of white cells ( 32888494)
  • Granulocyte count ( 27863252)
  • Hematocrit ( 32888494)
  • Hemoglobin ( 32888494)
  • Left superior temporal gyrus thickness (schizophrenia interaction) ( 26249676)
  • Lymphocyte counts ( 32888494)
  • Monocyte count ( 32888494 27863252)
  • Myeloid white cell count ( 27863252)
  • Myocardial infarction ( 26343387)
  • Myocardial infarction (early onset) ( 19198609)
  • Neutrophil count ( 32888494 27863252)
  • QT interval (ambient particulate matter interaction) ( 28749367)
  • Red blood cell count ( 32888494)
  • Resistance to Mycobacterium tuberculosis in HIV-positive individuals measured by a negative tuberculin skin test (continuous) ( 28628665)
  • Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
  • Schizophrenia ( 23212062)
  • Smoking initiation (ever regular vs never regular) ( 31089300)
  • Sum basophil neutrophil counts ( 27863252)
  • Sum neutrophil eosinophil counts ( 27863252)
  • White blood cell count ( 32888494 27863252)
Interacting Genes 30 interacting genes: CCL11 CCL13 CCL20 CCL21 CCL25 CCL26 CCL28 CCL5 CD4 CTSG CXCL10 CXCL11 CXCL14 CXCL17 CXCL2 CXCL6 CXCL9 CXCR4 DAZAP2 DPP4 ELANE FBXO7 FN1 MMP2 PF4 PF4V1 PPBP VCAN XCL1 XCL2 32 interacting genes: CCL13 CCL21 CCL26 CCL28 CCL5 CCL8 CELF1 CMTM6 COPG1 COPS7A COX17 CTSG CXCL10 CXCL11 CXCL12 CXCL14 CXCL6 CXCL9 CXCR1 CXCR2 DMWD EFNA1 MAPK6 MOB3B NDUFB11 NR4A1 PLEKHJ1 PMAIP1 RAB10 RPS27 SCFD1 STRN4
Entrez ID 6387 5473
HPRD ID 02904 07171
Ensembl ID ENSG00000107562 ENSG00000163736
Uniprot IDs P48061 P02775
PDB IDs 1A15 1QG7 1SDF 1VMC 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2KEE 2KOL 2N55 2NWG 2SDF 3GV3 3HP3 4LMQ 4UAI 6SHR 1F9P 1NAP 1TVX
Enriched GO Terms of Interacting Partners?
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