SRL and KCNIP3

Data Source:
BioGRID (two hybrid)

		SRL	KCNIP3
Description		sarcalumenin	potassium voltage-gated channel interacting protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Intracellular Membrane-bounded Organelle	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	GTP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding
	Biological Process	Endocytosis Endosomal Transport	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways			Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) PR interval ( 32439900) QT interval ( 24952745)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		3 interacting genes: KCNIP3 SGTA VSNL1	26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16
Entrez ID		6345	30818
HPRD ID		19351	05232
Ensembl ID		ENSG00000185739	ENSG00000115041
Uniprot IDs		B3KPP4 Q86TD4	A0A024RE22 Q9Y2W7
PDB IDs			2E6W
Enriched GO Terms of Interacting Partners?
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