CLIP1 and TUBB

Data Source:
BioGRID (pull down)

		CLIP1	TUBB
Description		CAP-Gly domain containing linker protein 1	tubulin beta class I
Image
GO Annotations	Cellular Component	Kinetochore Ruffle Nucleus Cytoplasm Centrosome Cytosol Microtubule Intermediate Filament Microtubule Cytoskeleton Cytoplasmic Vesicle Membrane Microtubule Plus-end Macropinosome	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytoskeleton Microtubule Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Microtubule Binding Zinc Ion Binding Tubulin Binding Microtubule Plus-end Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding
	Biological Process	Mitotic Cell Cycle Microtubule Bundle Formation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cellular Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Regulation Of Synapse Organization Spindle Assembly Cell Division Ciliary Basal Body-plasma Membrane Docking
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases activate IQGAPs RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs			Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Adiponectin levels ( 31178129) Body mass index ( 26961502 25673413) Chronotype ( 30696823) Hip circumference ( 25673412) Weight ( 28552196)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287)
Interacting Genes		13 interacting genes: BIN1 CALM1 CLASP2 CLIP4 DCTN1 IQGAP1 MAPRE2 MTOR PAFAH1B1 REL TSC22D2 TUBA1A TUBB	73 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CDKN2A CLIP1 CMTM5 CNN1 CRIPT DISC1 DPYSL2 DUX4 DYNLL1 ESR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 PFDN4 PLK1 PRKN PTEN RAB8B RACK1 RASSF1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TGM2 TINF2 TPPP TTBK1 TTK TUBA1A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19
Entrez ID		6249	203068
HPRD ID		01568	01852
Ensembl ID		ENSG00000130779	ENSG00000196230
Uniprot IDs		A0A024RBR1 B3KXA5 P30622	B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16
PDB IDs		2CP5 2CP6 2E3H 2E3I 2E4H 2HQH 2QK0 3E2U 3RDV	3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ
Enriched GO Terms of Interacting Partners?
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