RPL11 and GRWD1

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		RPL11	GRWD1
Description		ribosomal protein L11	glutamate rich WD repeat containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Polysomal Ribosome Extracellular Exosome	Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Protein-containing Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Inhibitor Activity	Chromatin Binding DNA Replication Origin Binding RNA Binding Protein Binding Histone Binding
	Biological Process	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation RRNA Processing Translation Translational Initiation Protein Targeting SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Gene Expression Viral Transcription Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation	DNA Replication Nucleosome Assembly Nucleosome Disassembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases		Diamond-Blackfan anemia (DBA)
GWAS
Interacting Genes		24 interacting genes: APP ARFGAP1 BLMH CAMK2B CDKN2A DVL3 GRWD1 HP HSPB2 IGF1R IP6K1 KRT40 KRTAP10-7 LIG4 MDM2 OSBPL3 PAIP2 PCAT1 PML SENP1 STAT3 TIGAR TP73 UBE2I	6 interacting genes: CDC42 ESR1 PCAT1 RPL11 RPL23 TP53
Entrez ID		6135	83743
HPRD ID		10364	11013
Ensembl ID		ENSG00000142676	ENSG00000105447
Uniprot IDs		P62913 Q5VVD0	Q9BQ67
PDB IDs		4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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