RPL11 and PAIP2

Data Source:
BioGRID (two hybrid)

		RPL11	PAIP2
Description		ribosomal protein L11	poly(A) binding protein interacting protein 2
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Cytosolic Large Ribosomal Subunit Protein-containing Complex Polysomal Ribosome Extracellular Exosome	Cytoplasm
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding 5S RRNA Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Inhibitor Activity	Translation Repressor Activity, MRNA Regulatory Element Binding MRNA Binding Protein Binding Translation Repressor Activity
	Biological Process	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation RRNA Processing Translation Translational Initiation Protein Targeting SRP-dependent Cotranslational Protein Targeting To Membrane Positive Regulation Of Gene Expression Viral Transcription Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Ribosomal Large Subunit Biogenesis Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Neddylation	Spermatogenesis Memory Negative Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Long-term Synaptic Potentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases		Diamond-Blackfan anemia (DBA)
GWAS			Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Malaria ( 31844061)
Interacting Genes		24 interacting genes: APP ARFGAP1 BLMH CAMK2B CDKN2A DVL3 GRWD1 HP HSPB2 IGF1R IP6K1 KRT40 KRTAP10-7 LIG4 MDM2 OSBPL3 PAIP2 PCAT1 PML SENP1 STAT3 TIGAR TP73 UBE2I	7 interacting genes: APP ELAVL1 PABPC1 PABPC5 RPL11 TRIM54 UBR5
Entrez ID		6135	51247
HPRD ID		10364	05726
Ensembl ID		ENSG00000142676	ENSG00000120727
Uniprot IDs		P62913 Q5VVD0	Q49AE6 Q9BPZ3
PDB IDs		4UG0 4V6X 4XXB 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO	1JGN 3KUS 3KUT
Enriched GO Terms of Interacting Partners?
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