RPA3 and RPA4

Data Source:
HPRD (in vitro, in vivo)

		RPA3	RPA4
Description		replication protein A3	replication protein A4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding	Single-stranded DNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Regulation Of Mitotic Cell Cycle Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Interstrand Cross-link Repair Regulation Of Cell Population Proliferation Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation Nucleotide-excision Repair Nuclear DNA Replication
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination	Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Estimated glomerular filtration rate ( 29779033) Insulin-like growth factors ( 21216879) Intraocular pressure ( 30591961) Serum creatinine levels ( 29779033) Urate levels in obese individuals ( 25811787)
Interacting Genes		10 interacting genes: ATRIP CDC5L ERCC1 MCM2 PRPF19 RAD51 RFWD3 RPA1 RPA2 RPA4	8 interacting genes: APP MSH2 MSH3 MUTYH PTRHD1 RPA1 RPA3 XPA
Entrez ID		6119	29935
HPRD ID		01567	06591
Ensembl ID		ENSG00000106399	ENSG00000204086
Uniprot IDs		A4D105 P35244	Q13156
PDB IDs		1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF
Enriched GO Terms of Interacting Partners?
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