RPA2 and AKAP9

Data Source:
BioGRID (two hybrid)

		RPA2	AKAP9
Description		replication protein A2	A-kinase anchoring protein 9
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Intracellular Membrane-bounded Organelle Synaptic Membrane Glutamatergic Synapse
	Molecular Function	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding G-rich Strand Telomeric DNA Binding	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Molecular Adaptor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Translesion Synthesis Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Protein Localization To Chromosome Interstrand Cross-link Repair Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Checkpoint	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization
Pathways		Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2
Drugs
Diseases			Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		HDL cholesterol levels ( 32203549) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)
Interacting Genes		63 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNC CCNO CDC5L CDK1 CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 EIF4G2 ERCC1 ERCC4 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED1 MED31 MEN1 NDEL1 ORC1 ORC2 ORC4 ORC5 PCM1 PPP4C PRC1 PRKCI PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA YWHAE ZBTB14	85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE
Entrez ID		6118	10142
HPRD ID		01566	04921
Ensembl ID		ENSG00000117748	ENSG00000127914
Uniprot IDs		B4DUL2 P15927	Q5GIA7 Q6PJH3 Q99996
PDB IDs		1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0
Enriched GO Terms of Interacting Partners?
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