AKAP9 and PRC1

Data Source:
BioGRID (two hybrid)

		AKAP9	PRC1
Description		A-kinase anchoring protein 9	protein regulator of cytokinesis 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Golgi Stack Cis-Golgi Network Centrosome Cytosol Cytoskeleton Voltage-gated Potassium Channel Complex Intracellular Membrane-bounded Organelle Synaptic Membrane Glutamatergic Synapse	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Spindle Microtubule Plasma Membrane Microtubule Cytoskeleton Midbody Intercellular Bridge Contractile Ring Mitotic Spindle Midzone
	Molecular Function	DNA Binding Signaling Receptor Binding Protein Binding Potassium Channel Regulator Activity Protein Kinase A Regulatory Subunit Binding Ion Channel Binding Molecular Adaptor Activity	Protein Binding Microtubule Binding Kinesin Binding Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Signal Transduction Chemical Synaptic Transmission Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Centrosome Location Regulation Of Membrane Repolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction Cellular Response To CAMP Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Postsynaptic Neurotransmitter Receptor Activity Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Golgi Organization	Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Microtubule Bundle Formation Positive Regulation Of Cell Population Proliferation Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Cell Division
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Phase 3 - rapid repolarisation Phase 2 - plateau phase Anchoring of the basal body to the plasma membrane Signaling by BRAF and RAF fusions AURKA Activation by TPX2	RHO GTPases activate CIT
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Breast cancer ( 29059683) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Red blood cell count ( 32888494)	Breast cancer ( 29059683 25038754) Mean platelet volume ( 32888494 27863252) Multisite chronic pain ( 31194737) Red cell distribution width ( 32888494) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 32499647 20581827 30718926 28869590)
Interacting Genes		85 interacting genes: ABI2 BEX2 BLZF1 C1orf94 CALM1 CALM2 CALM3 CASK CCDC116 CCDC146 CCP110 CDC5L CEP55 CLIC1 CSNK1D CSNK1E CTBP1 CTNNA3 DVL2 FAM90A1 FMR1 FNBP1 FXR2 GLIS2 GPC4 GRIN1 GTSE1 HDDC3 HNRNPM IKZF3 KCNQ1 KDM1A KIF19 KLC4 LMO1 MAGEA6 MAGED1 MED1 MYO5A NDEL1 PARD6G PCM1 PCNT PKN1 PKP2 PPP1CA PPP2R1B PPP2R3A PRC1 PRDM14 PRKAR2A PRKAR2B PRKCE RBM10 RBM14 RPA2 RSRC2 SAMD3 SCNM1 SF3B2 SLAIN1 SNF8 SNRPB SSX2 SSX3 SSX5 SUV39H2 TACC3 TCEANC TDP2 TENT5B THAP1 THOC1 TLX3 TNIK TRIP10 TSG101 TSNAX TUBGCP3 TULP3 USHBP1 USO1 VPS9D1 WAC YWHAE	29 interacting genes: AKAP9 CASK CCDC85B CCNA2 CCNB1 CCNE1 CDK1 CDK2 CINP FXR2 KIF3B KIF4A KLC2 KLC4 KRT20 MAT2A NDEL1 PCM1 PKIA PLK1 RACGAP1 RBM10 RPA2 SF3B2 SLAIN1 SUMO2 TRIM37 USHBP1 YWHAE
Entrez ID		10142	9055
HPRD ID		04921	17899
Ensembl ID		ENSG00000127914	ENSG00000198901
Uniprot IDs		Q5GIA7 Q6PJH3 Q99996	A0A024RC67 O43663
PDB IDs			3NRX 3NRY 4L3I 4L6Y 5KMG
Enriched GO Terms of Interacting Partners?
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