RPGR and IFT88

Data Source:
HPRD (in vivo)

		RPGR	IFT88
Description		retinitis pigmentosa GTPase regulator	intraflagellar transport 88
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum	Cytoplasm Centrosome Centriole Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Sperm Flagellum Ciliary Tip Ciliary Base Non-motile Cilium
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Kinesin Binding
	Biological Process	Intracellular Protein Transport Visual Perception Intraciliary Transport Regulation Of Catalytic Activity Response To Stimulus Cilium Assembly	Kidney Development Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Cilium Assembly Non-motile Cilium Assembly Regulation Of Autophagosome Assembly
Pathways			Hedgehog 'off' state Intraflagellar transport Intraflagellar transport Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS			Coronary artery calcification ( 23870195) Dental caries ( 23064961) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		14 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE	10 interacting genes: CAPN7 CCDC120 EEF2KMT EML2 FBXO7 ITPKB MSRB1 PRRC2A RPGR SMARCE1
Entrez ID		6103	8100
HPRD ID		02425	09000
Ensembl ID		ENSG00000156313	ENSG00000032742
Uniprot IDs		Q92834	A0A140VJL7 B3KX42 Q13099
PDB IDs		4JHN 4JHP 4QAM
Enriched GO Terms of Interacting Partners?
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