PYGO1 and SPTBN1

Data Source:
BioGRID (two hybrid)

		PYGO1	SPTBN1
Description		pygopus family PHD finger 1	spectrin beta, non-erythrocytic 1
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GO Annotations	Cellular Component	Nucleoplasm	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Extracellular Exosome
	Molecular Function	Protein Binding Methylated Histone Binding Metal Ion Binding	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Cadherin Binding GTPase Binding
	Biological Process	Kidney Development Hematopoietic Progenitor Cell Differentiation Spermatid Nucleus Differentiation Protein Localization To Nucleus Positive Regulation Of Transcription By RNA Polymerase II Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	MAPK Cascade Mitotic Cytokinesis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Plasma Membrane Organization Cytoskeleton Organization Axon Guidance Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins
Drugs			Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 19801982 18445777) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 29617998 29785010 31959993 30054594 30591961) Lumbar spine bone mineral density ( 29499414 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: BCL9 CARM1 CTNNB1 LENG8 PRMT6 SPTBN1	49 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 EIF3H EPB41 EPB41L3 GOLGA6L10 GRB2 GRIA2 HSPB1 MAPK14 MEF2C NF2 NOP53 PACSIN1 PJA1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 YWHAG ZNF251 ZNF512B
Entrez ID		26108	6711
HPRD ID		06064	01683
Ensembl ID		ENSG00000171016	ENSG00000115306
Uniprot IDs		Q9Y3Y4	B2ZZ89 Q01082
PDB IDs		2VP7 2VPB 2VPD 2VPE 2VPG	1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?
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