BACH2 and MLX

Data Source:
BioGRID (two hybrid)

		BACH2	MLX
Description		BTB domain and CNC homolog 2	MAX dimerization protein MLX
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Import Into Nucleus Primary Adaptive Immune Response Involving T Cells And B Cells	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			ChREBP activates metabolic gene expression ChREBP activates metabolic gene expression
Drugs
Diseases		Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203) Basophil count ( 32888494) Celiac disease ( 22057235 20190752 24999842 30572963) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive performance ( 20125193) Crohn's disease ( 28067908 21102463) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) General risk tolerance (MTAG) ( 30643258) Graves' disease ( 21841780 22922229) Height ( 28552196) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 27182965) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Interleukin-6 levels ( 22205395) Keratinocyte cancer (MTAG) ( 31174203) Latent autoimmune diabetes ( 30254083) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602 21833088) Nasal polyps ( 30643255) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Obesity-related traits ( 23251661) Plateletcrit ( 32888494) Primary central nervous system lymphoma ( 31102405) Primary sclerosing cholangitis ( 23603763 27992413) Red blood cell count ( 32888494) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Rheumatoid arthritis ( 30572963 23143596) Serum urate levels in chronic kidney disease ( 30181573) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568) Thyroid peroxidase antibody positivity ( 24586183) Thyroid peroxidase autoantibody levels in type 1 diabetes ( 21829393) Type 1 diabetes ( 21829393 25751624 19430480 30572963 18840781 18978792) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 27723757 22561518) White blood cell count ( 32888494 27863252)	Crohn's disease ( 21102463) Type 2 diabetes ( 30297969 29632382 30718926) Type 2 diabetes (time to event) ( 32589924)
Interacting Genes		46 interacting genes: ANKRD55 AP1M1 BAHD1 BATF3 CBX8 CCDC185 CENPP CFAP58 CTSZ CWF19L2 DDIT3 ELOA ENPP7 FAM161A FARS2 FOSL2 HMG20A INSYN2A KAT5 LUZP4 MAFF MAFG MAFK MCRS1 MLX NFE2L1 NFE2L3 NXF1 PATZ1 PSMC5 RPL9 RPP25 SCNM1 SLC43A1 SMYD1 TCEA2 TRAF4 TRIM42 TSHZ2 TULP3 ZBTB24 ZBTB34 ZNF124 ZNF438 ZNF774 ZNF792	31 interacting genes: APP BACH2 BEND7 CASK CCT6A DDIT4L GABARAPL1 GABARAPL2 ID3 KRTAP13-3 LNX1 LNX2 MAD1L1 MEI4 MEOX1 MEOX2 MLXIP MLXIPL MNT MXD1 MXD4 PIAS2 RBM39 RHBDD2 SAP30BP TEPSIN TLE5 TNNT2 UBE2I ZBTB32 ZNF620
Entrez ID		60468	6945
HPRD ID		12012	04278
Ensembl ID		ENSG00000112182	ENSG00000108788
Uniprot IDs		Q9BYV9	Q9UH92
PDB IDs		3OHU 3OHV
Enriched GO Terms of Interacting Partners?
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